Publications

Vaccine for leishmaniasis: New era of CRISPR generated Live attenuated dermotropic Leishmania

^{J Cell Mol Med. 2022 Mar 21; 1(1):12-16. doi: 10.46439/immunol.1.004}

Translational development of a tumor junction opening technology

^{Nature. 2022 May 11; Scientific Reports; Article number: 7753 (2022).}

Development of a process for large scale production of PfRH5 in E. coli expression system.

^{Int J Biol Macromol. 2021 Aug 6;188:169-179. doi: 10.1016/j.ijbiomac.2021.08.014.}

Preclinical validation of a live attenuated dermotropic Leishmania vaccine against vector transmitted fatal visceral leishmaniasis.

^{Commun Biol. 2021 Jul; 4(1):929. doi: 10.1038/s42003-021-02446-x.}

Unsatisfactory quality of E. coli asparaginase biogenerics in India: Implications for clinical outcomes in acute lymphoblastic leukaemia.

^{Pediatr Blood Cancer. 2021; 3;e29046. doi:10.1002/pbc.29046.}

Insights into interplay of immunopathophysiological events and molecular mechanistic cascades in psoriasis and its associated comorbidities.

^{J Autoimmun. 2021; 118:102614. doi: 10.1016/j.jaut.2021.102614} 

The Plasmodium falciparum circumsporozoite protein produced in Lactococcus lactis is pure and stable.

^{J Biol Chem. 2020 Jan 10;295(2):403-414. doi: 10.1074/jbc.RA119.011268.}

Malaria vaccine candidate based on Duffy-binding protein elicits strain transcending functional antibodies in a Phase I trial.

^{NPJ Vaccines. 2018 Sep 28;3:48. doi: 10.1038/s41541-018-0083-3. eCollection 2018. PubMed PMID: 30302285; PubMed Central PMCID: PMC6162314.}

The Leishmania donovani IMPACT-like protein possesses non-specific nuclease activity.

^{Int J Biol Macromol. 2018 Nov;119:962-973. doi: 10.1016/j.ijbiomac.2018.07.175.}

Activation of HRI is mediated by Hsp90 during stress through modulation of the HRI-Hsp90 complex.

^{Int J Biol Macromol. 2018 Oct 15;118(Pt B):1604-1613. doi: 10.1016/j.ijbiomac.2018.06.204. Epub 2018 Jul 3. PubMed PMID: 30170366.}

Elucidation of molecular mechanism of stability of the heme-regulated eIF2α kinase upon binding of its ligand, hemin in its catalytic kinase domain.

^{J Biomol Struct Dyn. 2018 Aug;36(11):2845-2861. doi: 10.1080/07391102.2017.1368417. Epub 2017 Sep 12. PubMed PMID: 28814160.}

HRI, a stress response eIF2α kinase, exhibits structural and functional stability at high temperature and alkaline conditions.

^{Int J Biol Macromol. 2017 Feb;95:528-538. doi: 10.1016/j.ijbiomac.2016.11.071. Epub 2016 Nov 22. PubMed PMID: 27888007.}

Robust antibody and CD8⁺ T-cell responses induced by P. falciparum CSP adsorbed to cationic liposomal adjuvant CAF09 confer sterilizing immunity against experimental rodent malaria infection.

^{NPJ Vaccines. 2017;2. pii: 10. doi: 10.1038/s41541-017-0011-y. Epub 2017 Apr 10. PubMed PMID: 28936360; PubMed Central PMCID: PMC5603302.}

Transmission-blocking activity of antibodies to Plasmodium falciparum GLURP.10C chimeric protein formulated in different adjuvants.

^{Malar J. 2015 Nov 9;14:443. doi: 10.1186/s12936-015-0972-0. PubMed PMID: 26552428; PubMed Central PMCID: PMC4640242.}

Association of antibodies to Plasmodium falciparum reticulocyte binding protein homolog 5 with protection from clinical malaria.

^{Front Microbiol. 2014 Jun 30;5:314. doi: 10.3389/fmicb.2014.00314. eCollection 2014. PubMed PMID: 25071730; PubMed Central PMCID: PMC4074990.}

Full-length Plasmodium falciparum circumsporozoite protein administered with long-chain poly(I·C) or the Toll-like receptor 4 agonist glucopyranosyl lipid adjuvant-stable emulsion elicits potent antibody and CD4+ T cell immunity and protection in mice.

^{Infect Immun. 2013 Mar;81(3):789-800. doi: 10.1128/IAI.01108-12.}

Conserved and variant epitopes of Plasmodium vivax Duffy binding protein as targets of inhibitory monoclonal antibodies.

^{Infect Immun. 2012 Mar;80(3):1203-8. doi: 10.1128/IAI.05924-11. Epub 2012 Jan 3. PubMed PMID: 22215740; PubMed Central PMCID: PMC3294652.}

Nrf2 regulates hyperoxia-induced Nox4 expression in human lung endothelium: identification of functional antioxidant response elements on the Nox4 promoter.

^{Free Radic Biol Med. 2011 Jun 15;50(12):1749-59. doi: 10.1016/j.freeradbiomed.2011.03.022. Epub 2011 Mar 26. PubMed PMID: 21443946; PubMed Central PMCID: PMC3454485.}

Elaxim^®

Pharmacological Reperfusion Therapy with Tenecteplase in 7,668 Indian Patients with ST Elevation Myocardial Infarction – A Real World Indian Experience.

^{J Assoc Physicians India. 2017 Sep;65(9):43-47.}

Pharmacologic Reperfusion Therapy with Indigenous Tenecteplase in 15,222 patients with ST Elevation Myocardial Infarction – The Indian Registry

^{Indian Heart J. 2013;65(4):436–441. doi:10.1016/j.ihj.2013.06.010}

Tenecteplase in the treatment of acute pulmonary thrombo-embolism.

^{J Thromb Thrombolysis. 2011 May;31(4):445-8. doi: 10.1007/s11239-010-0524-y.}

Efficacy and safety of tenecteplase in diabetic and non-diabetic patients of STEMI – Indian registry data

^{J Assoc Physicians India. 2010 Apr;58:229-30.}

Tenectase^®

Efficacy and Safety of Intravenous Tenecteplase Bolus in Acute Ischemic Stroke: Results of Two Open-Label, Multicenter Trials.

^{Am J Cardiovasc Drugs. 2018 Oct;18(5):387-395. doi: 10.1007/s40256-018-0284-1.}

Hamsyl^®

Randomized, Parallel Group, Open-Label Bioequivalence Trial of Intramuscular Pegaspargase in Patients With Relapsed Acute Lymphoblastic Leukemia

^{JCO Glob Oncol. 2020 Jul;6:1009-1016. doi: 10.1200/GO.20.00113.}

Experience with generic pegylated L-asparaginase in children with acute lymphoblastic leukemia and monitoring of serum asparaginase activity.

^{Pediatr Hematol Oncol. 2018 Aug – Sep;35(5-6):331-340. doi: 10.1080/08880018.2018.1538277}

Retrospective post-marketing study on the use of bio-similar pegasparagase among acute lymphoblastic leukemia patients in India

^{Pediatric Hematology Oncology Journal, Volume 3, Issue 1, March 2018, Pages 9-12}

Emgrast^®

Assessing analytical comparability of biosimilars: GCSF as a case study

^{J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Oct 1;1032:165-171. doi: 10.1016/j.jchromb.2016.05.027.}

PEGEX^®

Establishment of the first international standard for PEGylated granulocyte colony stimulating factor (PEG-G-CSF): Report of an international collaborative study

^{J Immunol Methods. 2015 Jan;416:17-28. doi: 10.1016/j.jim.2014.10.005.}