Research Articles – Gennova Bio https://gennova.bio Transforming Healthcare Thu, 09 Apr 2020 19:33:17 +0000 en-GB hourly 1 https://wordpress.org/?v=6.9.1 https://gennova.bio/wp-content/uploads/2020/01/cropped-Gennova-fav-icon-32x32.png Research Articles – Gennova Bio https://gennova.bio 32 32 Nrf2 regulates hyperoxia-induced Nox4 expression in human lung endothelium: identification of functional antioxidant response elements on the Nox4 promoter. https://gennova.bio/nrf2-regulates-hyperoxia-induced-nox4-expression-in-human-lung-endothelium-identification-of-functional-antioxidant-response-elements-on-the-nox4-promoter/ Thu, 09 Apr 2020 18:25:09 +0000 http://localhost/gennova/?p=10544 Free Radic Biol Med. 2011 Jun 15;50(12):1749-59. doi: 10.1016/j.freeradbiomed.2011.03.022. Epub 2011 Mar 26. PubMed PMID: 21443946; PubMed Central PMCID: PMC3454485.

https://www.ncbi.nlm.nih.gov/pubmed/?term=21443946

]]> Conserved and variant epitopes of Plasmodium vivax Duffy binding protein as targets of inhibitory monoclonal antibodies. https://gennova.bio/conserved-and-variant-epitopes-of-plasmodium-vivax-duffy-binding-protein-as-targets-of-inhibitory-monoclonal-antibodies/ Thu, 09 Apr 2020 18:24:26 +0000 http://localhost/gennova/?p=10542 Infect Immun. 2012 Mar;80(3):1203-8. doi: 10.1128/IAI.05924-11. Epub 2012 Jan 3. PubMed PMID: 22215740; PubMed Central PMCID: PMC3294652.

https://www.ncbi.nlm.nih.gov/pubmed/?term=22215740

]]> Full-length Plasmodium falciparum circumsporozoite protein administered with long-chain poly(I·C) or the Toll-like receptor 4 agonist glucopyranosyl lipid adjuvant-stable emulsion elicits potent antibody and CD4+ T cell immunity and protection in mice. https://gennova.bio/full-length-plasmodium-falciparum-circumsporozoite-protein-administered-with-long-chain-polyi%c2%b7c-or-the-toll-like-receptor-4-agonist-glucopyranosyl-lipid-adjuvant-stable-emulsion-elicits-potent/ Thu, 09 Apr 2020 18:23:48 +0000 http://localhost/gennova/?p=10540 Infect Immun. 2013 Mar;81(3):789-800. doi: 10.1128/IAI.01108-12.

https://www.ncbi.nlm.nih.gov/pubmed/23275094

]]> Association of antibodies to Plasmodium falciparum reticulocyte binding protein homolog 5 with protection from clinical malaria. https://gennova.bio/association-of-antibodies-to-plasmodium-falciparum-reticulocyte-binding-protein-homolog-5-with-protection-from-clinical-malaria/ Thu, 09 Apr 2020 18:23:01 +0000 http://localhost/gennova/?p=10538 Front Microbiol. 2014 Jun 30;5:314. doi: 10.3389/fmicb.2014.00314. eCollection 2014. PubMed PMID: 25071730; PubMed Central PMCID: PMC4074990.

https://www.ncbi.nlm.nih.gov/pubmed/?term=25071730

]]> Transmission-blocking activity of antibodies to Plasmodium falciparum GLURP.10C chimeric protein formulated in different adjuvants. https://gennova.bio/transmission-blocking-activity-of-antibodies-to-plasmodium-falciparum-glurp-10c-chimeric-protein-formulated-in-different-adjuvants/ Thu, 09 Apr 2020 18:22:12 +0000 http://localhost/gennova/?p=10536 Malar J. 2015 Nov 9;14:443. doi: 10.1186/s12936-015-0972-0. PubMed PMID: 26552428; PubMed Central PMCID: PMC4640242.

https://www.ncbi.nlm.nih.gov/pubmed/?term=26552428

]]> Robust antibody and CD8+ T-cell responses induced by P. falciparum CSP adsorbed to cationic liposomal adjuvant CAF09 confer sterilizing immunity against experimental rodent malaria infection. https://gennova.bio/robust-antibody-and-cd8-t-cell-responses-induced-by-p-falciparum-csp-adsorbed-to-cationic-liposomal-adjuvant-caf09-confer-sterilizing-immunity-against-experimental-rodent-malaria-infection/ Thu, 09 Apr 2020 18:21:30 +0000 http://localhost/gennova/?p=10534 NPJ Vaccines. 2017;2. pii: 10. doi: 10.1038/s41541-017-0011-y. Epub 2017 Apr 10. PubMed PMID: 28936360; PubMed Central PMCID: PMC5603302.

https://www.ncbi.nlm.nih.gov/pubmed/?term=28936360

]]> HRI, a stress response eIF2α kinase, exhibits structural and functional stability at high temperature and alkaline conditions. https://gennova.bio/hri-a-stress-response-eif2%ce%b1-kinase-exhibits-structural-and-functional-stability-at-high-temperature-and-alkaline-conditions/ Thu, 09 Apr 2020 18:20:34 +0000 http://localhost/gennova/?p=10532 Int J Biol Macromol. 2017 Feb;95:528-538. doi: 10.1016/j.ijbiomac.2016.11.071. Epub 2016 Nov 22. PubMed PMID: 27888007.

https://www.ncbi.nlm.nih.gov/pubmed/?term=27888007

]]> Elucidation of molecular mechanism of stability of the heme-regulated eIF2α kinase upon binding of its ligand, hemin in its catalytic kinase domain. https://gennova.bio/elucidation-of-molecular-mechanism-of-stability-of-the-heme-regulated-eif2%ce%b1-kinase-upon-binding-of-its-ligand-hemin-in-its-catalytic-kinase-domain/ Thu, 09 Apr 2020 18:19:52 +0000 http://localhost/gennova/?p=10530 J Biomol Struct Dyn. 2018 Aug;36(11):2845-2861. doi: 10.1080/07391102.2017.1368417. Epub 2017 Sep 12. PubMed PMID: 28814160.

https://www.ncbi.nlm.nih.gov/pubmed/?term=28814160

]]> Activation of HRI is mediated by Hsp90 during stress through modulation of the HRI-Hsp90 complex. https://gennova.bio/activation-of-hri-is-mediated-by-hsp90-during-stress-through-modulation-of-the-hri-hsp90-complex/ Thu, 09 Apr 2020 18:19:06 +0000 http://localhost/gennova/?p=10528 Int J Biol Macromol. 2018 Oct 15;118(Pt B):1604-1613. doi: 10.1016/j.ijbiomac.2018.06.204. Epub 2018 Jul 3. PubMed PMID: 30170366.

https://www.ncbi.nlm.nih.gov/pubmed/?term=30170366

]]> The Leishmania donovani IMPACT-like protein possesses non-specific nuclease activity. https://gennova.bio/the-leishmania-donovani-impact-like-protein-possesses-non-specific-nuclease-activity/ Thu, 09 Apr 2020 18:18:22 +0000 http://localhost/gennova/?p=10526 Int J Biol Macromol. 2018 Nov;119:962-973. doi: 10.1016/j.ijbiomac.2018.07.175

https://www.ncbi.nlm.nih.gov/pubmed/30077668

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